CVE-2021-25921

CRITICALNVD 5.49.0▲
EchelonGraph scoreHIGH confidence

Score elevated to 9.0 because EPSS predicts 91% probability of exploitation within the next 30 days (top 0.2% of all CVEs). NVD baseline CVSS 5.4 retained for reference. Confidence: see factors.

Triggered by: EPSS exploit prediction ≥85%
Sources: epss, ghsa, nvd
Weaponized
9.0EG
EchelonGraph verdictPatch this weekExploitation is likely or a public exploit exists.
  • High exploitation likelihood — EPSS 91%
  • Public exploit code is available (ssvc poc, epss top5pct, epss high)
CISA-KEV: Not listedEPSS PROB: 91%CVSS: 5.4Exploit: ssvc poc · epss top5pct · epss highExposed: 0

No vendor fix yet — apply a workaround or compensating control (WAF / firewall / segmentation) and watch for a patch.

In OpenEMR, versions 2.7.3-rc1 to 6.0.0 are vulnerable to Stored Cross-Site-Scripting (XSS) due to user input not being validated properly in the Allergies section. An attacker could lure an admin to enter a malicious payload and by that initiate the exploit.

CVSS v3
5.4
EG Score
9.0(high)
EG Risk
77(Track)
EG Risk 77/100SSVC: Track

EG Risk is EchelonGraph's 0–100 priority score: it fuses intrinsic severity with real-world exploitation and automatability so you can rank equal-severity CVEs and fix the most dangerous first. Higher = act sooner. Distinct from the 0–10 EG Score (severity).

How it’s computed
Severity90% × 45%
Exploitation91% × 40%
Automatability0% × 15%
Action: Routine — remediate on your standard cadence.
EPSS PROB
91%
EPSS %ILE
100%
KEV
Not listed

Published

March 22, 2021

Last Modified

April 30, 2025

References (4)

Weakness Classification(1)

MITRE Common Weakness Enumeration — the root-cause categories this CVE belongs to.

Data Freshness Timeline

(refreshed 3× in last 7d / 16× in last 30d)

Each row is a source pipeline that fetched or updated this CVE on that date, with what changed. For example, "NVD update" means NVD published or revised its analysis for this CVE; "MITRE cvelistV5" means we ingested or refreshed it from the CNA feed. Most recent first.

  1. 2026-08-16 14:53 UTCEPSS rescore
  2. 2026-08-16 02:11 UTCEPSS rescore
  3. 2026-08-16 02:11 UTCEPSS rescore
  4. 2026-08-12 13:47 UTCEPSS rescore
  5. 2026-08-08 16:33 UTCEPSS rescore
  6. 2026-08-08 04:49 UTCOSV refresh
  7. 2026-08-05 19:14 UTCEPSS rescore
  8. 2026-07-30 01:28 UTCEPSS rescore
  9. 2026-07-30 01:27 UTCEPSS rescore
  10. 2026-07-26 14:52 UTCEPSS rescore
  11. 2026-07-26 14:52 UTCEPSS rescore
  12. 2026-07-25 14:15 UTCEPSS rescore
  13. 2026-07-24 14:15 UTCEPSS rescore
  14. 2026-07-23 01:58 UTCEG score recompute
  15. 2026-07-22 21:28 UTCEG score recompute▲ 3.60
  16. 2026-07-22 21:28 UTCGHSA enrichment
  17. 2026-07-22 14:06 UTCEPSS rescore
  18. 2026-07-22 14:06 UTCEPSS rescore
  19. 2026-07-18 23:59 UTCOSV refresh
  20. 2026-07-16 17:00 UTCEPSS rescore
  21. 2026-07-11 08:25 UTCEPSS rescore
  22. 2026-07-11 08:25 UTCEPSS rescore
  23. 2026-07-02 16:57 UTCEPSS rescore
  24. 2026-07-01 06:48 UTCOSV refresh
  25. 2026-06-24 14:03 UTCEPSS rescore
Show 39 more
  1. 2026-06-24 14:03 UTCEPSS rescore
  2. 2026-06-23 21:31 UTCEPSS rescore
  3. 2026-06-23 21:31 UTCEPSS rescore
  4. 2026-06-17 17:51 UTCEPSS rescore
  5. 2026-06-15 17:46 UTCEPSS rescore
  6. 2026-06-13 22:58 UTCEPSS rescore
  7. 2026-06-13 22:58 UTCEPSS rescore
  8. 2026-06-13 11:13 UTCOSV refresh
  9. 2026-06-12 23:10 UTCEPSS rescore
  10. 2026-06-11 13:58 UTCEPSS rescore
  11. 2026-06-10 22:16 UTCEPSS rescore
  12. 2026-06-10 13:20 UTCEPSS rescore
  13. 2026-06-08 14:15 UTCEPSS rescore
  14. 2026-06-06 13:46 UTCEPSS rescore
  15. 2026-06-06 13:46 UTCEPSS rescore
  16. 2026-06-06 13:46 UTCEPSS rescore
  17. 2026-06-05 22:45 UTCEPSS rescore
  18. 2026-06-05 22:45 UTCEPSS rescore
  19. 2026-06-05 06:09 UTCEPSS rescore
  20. 2026-06-05 06:09 UTCEPSS rescore
  21. 2026-06-04 13:10 UTCEPSS rescore
  22. 2026-06-04 13:10 UTCEPSS rescore
  23. 2026-06-02 20:11 UTCEPSS rescore
  24. 2026-06-02 20:11 UTCEPSS rescore
  25. 2026-06-02 20:11 UTCEPSS rescore
  26. 2026-06-01 13:50 UTCEPSS rescore
  27. 2026-06-01 13:50 UTCEPSS rescore
  28. 2026-05-31 22:29 UTCEPSS rescore
  29. 2026-05-31 22:29 UTCEPSS rescore
  30. 2026-05-31 00:15 UTCEPSS rescore
  31. 2026-05-29 13:42 UTCEPSS rescore
  32. 2026-05-28 13:43 UTCEPSS rescore
  33. 2026-05-28 13:43 UTCEPSS rescore
  34. 2026-05-27 13:39 UTCEPSS rescore
  35. 2026-05-27 13:39 UTCEPSS rescore
  36. 2026-05-26 19:33 UTCEG score recompute
  37. 2026-05-26 19:33 UTCGHSA enrichment
  38. 2026-05-26 07:17 UTCEPSS rescore
  39. 2026-05-26 07:17 UTCEPSS rescore

Frequently asked(5)

What is CVE-2021-25921?
CVE-2021-25921 is a critical vulnerability published on March 22, 2021. In OpenEMR, versions 2.7.3-rc1 to 6.0.0 are vulnerable to Stored Cross-Site-Scripting (XSS) due to user input not being validated properly in the Allergies section. An attacker could lure an admin to enter a malicious payload and by that initiate the exploit.
When was CVE-2021-25921 disclosed?
CVE-2021-25921 was first published in the National Vulnerability Database on March 22, 2021, with the most recent update on April 30, 2025. EchelonGraph re-ingests CVE updates from NVD on a 2-hour cycle, so this page reflects the latest published state.
Is CVE-2021-25921 actively exploited?
CVE-2021-25921 is not currently on CISA's Known Exploited Vulnerabilities catalog. FIRST EPSS estimates a 91% probability of exploitation in the next 30 days, which ranks it in the top 0.2% of all scored CVEs.
What is the CVSS score of CVE-2021-25921?
CVE-2021-25921 has a CVSS v3 base score of 5.4 (NVD). EchelonGraph synthesises NVD + CISA KEV + FIRST EPSS + GHSA into a combined EG score of 9.0.
How do I remediate CVE-2021-25921?
Patch to the fixed version published by the affected vendor. Where vendor advisories exist for CVE-2021-25921, EchelonGraph cross-links them in the Vendor Advisories panel below — those typically contain the canonical remediation steps, fixed version numbers, and any vendor-specific mitigations.

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